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    The Octopus Mystery Continues As They Evolve Differently From Nearly Every Other Organism On Earth

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    This edited message then produces proteins that also have modifications. RNA editing was first described in by researchers studying single-celled parasites closely related to the microbe responsible for causing sleeping sickness.

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    This genetic instruction manual is written in a four-letter language and describes how to build all the different proteins an organism can construct.

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    This premise has underpinned much of our understanding of genetics since we discovered that genetic information is stored as DNA.

    But recent research has shown that octopuses, squid, and cuttlefish do not always follow their genetic instructions to the letter. This edited message then produces proteins that also have modifications.

    RNA editing was first described in by researchers studying single-celled parasites closely related to the microbe responsible for causing sleeping sickness.

    Since then, RNA editing has been seen as relatively unimportant in animals. Humans, for example, have only a handful of RNA editing sites in their protein coding sequences.

    However, in the remarkably intelligent squid, RNA editing affects most genes associated with the nervous system.

    This suggests that, in certain groups of organisms, the practice may play an important role. By comparing how often RNA editing occurs within the cephalopod family, the new study identified when in evolutionary history this ability to alter genetic messages appeared.

    The researchers showed that widespread RNA editing evolved in the common ancestor of the exceptional behaviourally sophisticated octopuses, squid and cuttlefish.

    And that it is lacking in the relatively simple-minded nautilus, a more distant relative. RNA editing is thought to give cephalopods an evolutionary advantage by increasing the variation in the proteins they produce.

    This enables them to rapidly adapt to changing environments. For example, we know RNA editing allows octopuses to deal with dramatic changes in temperature and so survive in frigid polar waters.

    But this recent study also suggests that there may be a trade-off between this ability to adapt quickly and the long-term process of Darwinian DNA evolution.

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